(Poster 155) Mood Changes After Pelvic Organ Prolapse Surgery: A Prospective Clinical Study

Objectives: To characterize mood changes in patients undergoing pelvic organ prolapse (POP) surgery, assess whether subclinical depression and anxiety predict psychiatric diagnosis within 12 weeks of surgery, and assess whether there is a correlation between postoperative mood disorders and postoperative outcomes.

Methods: Inclusion criteria are patients >/= 18 years, female, undergoing any surgical procedure for repair of POP, and English speaking. Participants were asked to complete the Beck Anxiety Questionnaire (BAQ), Beck Depression Questionnaire (BDQ), Female Sexual Function Index, Incontinence Impact Questionnaire 7 (IIQ), Pelvic Floor Disability Index 20 (PFDI), Short Form 36, and Urinary Distress Inventory 6 (UDI) with various survey combinations at the following time points: pre-surgery, day of surgery, and postoperative weeks 4, 8, and 12. Demographic information, psychiatric history, medical history, surgical history, intraoperative and postoperative complications, postoperative emergency room visits, and new psychiatric diagnoses were reviewed.

Results: 90 participants, mean age 59.9, were included in the preliminary data analysis. Over the study period mean BDQ scores decreased from 5.9 prior to surgery to 4.1 at week 12, mean BAQ scores decreased from 5.5 to 3.3, mean IIQ scores decreased from 19.8 to 9.8, mean PFDI scores decreased from 36.1 to 13.9, and mean UDI scores decreased from 30.1 to 14.9. In the study period, no participants were diagnosed with a new psychiatric disorder. Nine (10%) participants visited the ED/Urgent care for issues related to POP surgery and seven (7.8%) for other issues.

Conclusions: Average depression and anxiety scores decreased in patients undergoing POP surgery in the 12-week postoperative period. Improvements were also seen in the IIQ, PFDI, and UDI assessments. This study continues enrollment with the aim of achieving statistical significance and better understanding of postoperative mood changes in individuals undergoing POP surgery.